Parkash, Vivak orcid.org/0000-0001-9701-5767, Kaye, Paul M orcid.org/0000-0002-8796-4755, Layton, Alison M et al. (1 more author) (2021) Vaccines against leishmaniasis:using controlled human infection models to accelerate development. Expert Review of Vaccines. pp. 1407-1418. ISSN 1744-8395
Abstract
INTRODUCTION: Leishmaniasis is a neglected tropical disease that is defined by the World Health Organization as vaccine preventable. Although several new candidate vaccines are in development, no vaccine has successfully reached the market for human use. Several species of Leishmania cause human disease and have co-evolved with their respective sand fly vectors. These unique relationships have implications for initiation of infection and vaccine development. An approach to vaccine development for many infectious diseases is the use of controlled human infection models (CHIMs). AREAS COVERED: We describe the history and recent development of experimental and deliberate infection using Leishmania in humans and the rationale for developing a new sand fly-initiated CHIM to progress leishmaniasis vaccine development. Examples from other infectious diseases are discussed in the context of the development of a new leishmaniasis CHIM. We also reflect upon the manufacture of the challenge agent, practical considerations, safety, ethics, and regulatory issues. EXPERT OPINION: A new cutaneous Leishmania CHIM is being developed to enable testing of vaccines in the development pipeline. Questions remain about the use of such CHIMs to determine effectiveness of vaccines against visceral leishmaniasis. However, such a CHIM will be invaluable in expediting time to market for vaccines.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Author(s) |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 29 Oct 2021 08:40 |
Last Modified: | 07 Feb 2025 00:32 |
Published Version: | https://doi.org/10.1080/14760584.2021.1991795 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1080/14760584.2021.1991795 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:179770 |
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Filename: Vaccines_against_leishmaniasis_using_controlled_human_infection_models_to_accelerate_development.pdf
Description: Vaccines against leishmaniasis using controlled human infection models to accelerate development
Licence: CC-BY 2.5