Wang, L, Roger, S, Yang, XB orcid.org/0000-0002-0144-2826 et al. (1 more author) (2021) Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions. Frontiers in Bioscience - Landmark, 26 (12). pp. 1737-1745. ISSN 1093-9946
Abstract
It is well-known that extracellular ATP acts as an autocrine/paracrine signal to regulate cell functions by inducing intracellular Ca2+ signalling through its cognate receptors, namely, the ligand-gated ion channel P2X receptors that mediate Ca2+ influx and/or the Gq/11-coupled P2Y receptors that link to Ca2+ release from the ER. The reduction in ER Ca2+ can trigger further extracellular Ca2+ entry by activating the store-operated Ca2+ (SOC) channel. Mesenchymal stem cells (MSC) play an important role in the homeostasis of residing tissues and have promising applications in regenerative medicines. MSC can release ATP spontaneously or in response to diverse stimuli, and express multiple P2X and Gq/11-coupled P2Y receptors that participate in ATP-induced Ca2+ signalling and regulate cell function. There is increasing evidence to show the contribution of the SOC channel in ATP-induced Ca2+ signalling in MSC. In this mini-review, we discuss the current understanding of the expression of the SOC channel in MSC and its potential role in mediating ATP-induced Ca2+ signalling and regulation of MSC differentiation, proliferation and migration.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Author(s). Published by BRI. This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | Mesenchymal stem cells; Extracellular ATP; Ca2+ signalling; Store-operated Ca2+ channel |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Oct 2021 10:14 |
Last Modified: | 17 May 2022 06:25 |
Status: | Published |
Publisher: | Bioscience Research Institute |
Identification Number: | 10.52586/5065 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:179600 |