Kearney, KJ orcid.org/0000-0002-0387-6812, Ariëns, RAS and Macrae, FL orcid.org/0000-0002-7092-0422 (2021) The Role of Fibrin(ogen) in Wound Healing and Infection Control. Seminars in Thrombosis and Hemostasis, 48 (2). pp. 174-187. ISSN 0094-6176
Abstract
Fibrinogen, one of the most abundant plasma proteins playing a key role in hemostasis, is an important modulator of wound healing and host defense against microbes. In the current review, we address the role of fibrin(ogen) throughout the process of wound healing and subsequent tissue repair. Initially fibrin(ogen) acts as a provisional matrix supporting incoming leukocytes and acting as reservoir for growth factors. It later goes on to support re-epithelialization, angiogenesis, and fibroplasia. Importantly, removal of fibrin(ogen) from the wound is essential for wound healing to progress. We also discuss how fibrin(ogen) functions through several mechanisms to protect the host against bacterial infection by providing a physical barrier, entrapment of bacteria in fibrin(ogen) networks, and by directing immune cell function. The central role of fibrin(ogen) in defense against bacterial infection has made it a target of bacterial proteins, evolved to interact with fibrin(ogen) to manipulate clot formation and degradation for the purpose of promoting microbial virulence and survival. Further understanding of the dual roles of fibrin(ogen) in wound healing and infection could provide novel means of therapy to improve recovery from surgical or chronic wounds and help to prevent infection from highly virulent bacterial strains, including those resistant to antibiotics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021. Thieme. All rights reserved. This is an author produced version of a review article published in Seminars in Thrombosis and Hemostasis. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | fibrinogen; infection; wound healing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 215861/Z/19/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Oct 2021 13:10 |
Last Modified: | 24 Aug 2022 00:13 |
Status: | Published |
Publisher: | Thieme Gruppe |
Identification Number: | 10.1055/s-0041-1732467 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:178873 |