Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis

Caseley, EA orcid.org/0000-0001-7591-143X, Muench, SP orcid.org/0000-0001-6869-4414 and Jiang, L-H orcid.org/0000-0001-6398-0411 (2022) Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins: Structure, Function, and Bioinformatics, 90 (3). pp. 619-624. ISSN 0887-3585

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Item Type: Article
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© 2021 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Caseley, EA , Muench, SP and Jiang, L-H (2022) Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins: Structure, Function, and Bioinformatics, 90 (3). pp. 619-624. ISSN 0887-3585, which has been published in final form at [https://doi.org/10.1002/prot.26259]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Uploaded in accordance with the publisher's self-archiving policy.

Keywords: molecular docking, P2X7R, patch-clamp recording, site-directed mutagenesis, structural modeling, structure–function relationships
Dates:
  • Published: March 2022
  • Published (online): 8 October 2021
  • Accepted: 3 October 2021
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
Funding Information:
Funder
Grant number
Wellcome Trust
099758/Z/12/Z
Depositing User: Symplectic Publications
Date Deposited: 06 Oct 2021 12:09
Last Modified: 08 Oct 2022 00:15
Status: Published
Publisher: Wiley
Identification Number: 10.1002/prot.26259
Open Archives Initiative ID (OAI ID):

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