Frueh, J., Maimari, N., Lui, Y. et al. (11 more authors) (2012) Systems and synthetic biology of the vessel wall. FEBS Letters, 586 (15). pp. 2164-2170. ISSN 0014-5793
Abstract
Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Keywords: | ACS; acute coronary syndromes; csSAM; cell specific SAM; CV; coefficient of variation; GGM; graphical; GSEA; gene set enrichment analysis; PCA; principal component analysis; RMA; robust multi-array averaging; SAM; significance analysis of microarrays; TCFA; thin cap fibroatheroma; Systems medicine; Vascular; Mechanotransduction; Synthetic biology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Oct 2021 15:05 |
Last Modified: | 05 Oct 2021 15:05 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1016/j.febslet.2012.04.031 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:178759 |