Kis, Z., Pereira, H.S., Homma, T. et al. (2 more authors) (2015) Mammalian synthetic biology: emerging medical applications. Journal of the Royal Society, Interface, 12 (106). 20141000. ISSN 1742-5689
Abstract
In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON-OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug discovery, drug delivery, receptor-activating gene circuits and mammalian biomanufacturing processes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 The Author(s) Published by the Royal Society. |
Keywords: | gene therapy; mammalian cells; synthetic biology; Animals; Biotechnology; Drug Delivery Systems; Drug Discovery; Gene Regulatory Networks; Genes, Synthetic; Mammals; Synthetic Biology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Oct 2021 15:17 |
Last Modified: | 05 Oct 2021 15:17 |
Status: | Published |
Publisher: | The Royal Society |
Refereed: | Yes |
Identification Number: | 10.1098/rsif.2014.1000 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:178757 |