Taylor, JC orcid.org/0000-0002-2518-5799, Iversen, LH, Burke, D orcid.org/0000-0002-4342-7464 et al. (7 more authors) (2021) Influence of age on surgical treatment and postoperative outcomes of patients with colorectal cancer in Denmark and Yorkshire, England. Colorectal Disease, 23 (12). pp. 3152-3161. ISSN 1462-8910
Abstract
Aim
Denmark and Yorkshire are demographically similar and both have undergone changes in their management of colorectal cancer to improve outcomes. The differential provision of surgical treatment, especially in the older age groups, may contribute to the magnitude of improved survival rates. This study aimed to identify differences in the management of colorectal cancer surgery and postoperative outcomes according to patient age between Denmark and Yorkshire.
Method
This was a retrospective population-based study of colorectal cancer patients diagnosed in Denmark and Yorkshire between 2005 and 2016. Proportions of patients undergoing major surgical resection, postoperative mortality and relative survival were compared between Denmark and Yorkshire across several age groups (18–59, 60–69, 70–79 and ≥80 years) and over time.
Results
The use of major surgical resection was higher in Denmark than in Yorkshire, especially for patients aged ≥80 years (70.5% versus 50.5% for colon cancer, 49.3% versus 38.1% for rectal cancer). Thirty-day postoperative mortality for Danish patients aged ≥80 years was significantly higher than that for Yorkshire patients with colonic cancer [OR (95% CI) = 1.22 (1.07, 1.38)] but not for rectal cancer or for 1-year postoperative mortality. Relative survival significantly increased in all patients aged ≥80 years except for Yorkshire patients with colonic cancer.
Conclusion
This study suggests that there are major differences between the management of elderly patients with colorectal cancer between the two populations. Improved selection for surgery and better peri- and postoperative care in these patients appears to improve long-term outcomes, but may come at the cost of a higher 30-day mortality.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | colorectal cancer, elderly, mortality, surgical resection, survival |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds) |
Funding Information: | Funder Grant number Yorkshire Cancer Research L394 Cancer Research UK A24939 NIHR National Inst Health Research No Ext Ref Cancer Research UK C23434/A23706 |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Sep 2021 12:51 |
Last Modified: | 27 Jul 2022 09:41 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/codi.15910 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:178172 |