Wang, MJ, Zhu, YC and Shi, J (2021) A crucial physiological role of Piezo1 channel in differentiation rather than proliferation during myogenesis. Acta Physiologica, 233 (4). e13728. ISSN 1748-1708
Abstract
Mechanical signals are critical for the growth, maintenance and repair of skeletal muscle. However, it remained elusive whether the mechanically activated ion channels, notably the novel Piezo1 channel, mediate these functions in the muscle. Although an earlier report1 suggested that Piezo1 channel could be important for myoblast cell fusion and myotube elongation in the C2C12 cell line, the current study by Bosutti et al2 made significant progress in determining the physiological roles of Piezo1 channel in myogenesis and adult myofibre activity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is protected by copyright. All rights reserved. This is the peer reviewed version of the following article: Wang, MJ, Zhu, YC and Shi, J (2021) A crucial physiological role of Piezo1 channel in differentiation rather than proliferation during myogenesis. Acta Physiologica, 233 (4). e13728. ISSN 1748-1708, which has been published in final form at https://doi.org/10.1111/apha.13728. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation FS/17/2/32559 |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Sep 2021 10:18 |
Last Modified: | 07 Sep 2022 00:13 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/apha.13728 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:177939 |