Larvin, H orcid.org/0000-0001-7263-4182, Kang, J orcid.org/0000-0002-2770-1099, Aggarwal, VR orcid.org/0000-0003-0838-9682 et al. (2 more authors) (2021) Multimorbid disease trajectories for people with periodontitis. Journal of Clinical Periodontology, 48 (12). pp. 1587-1596. ISSN 0303-6979
Abstract
Aim
Periodontitis is a multifactorial condition linked to increased risk of systemic diseases. This study aimed to identify disease trajectories of people with periodontitis using the process mining technique as a heuristic approach.
Material and Methods
A total of 188,863 participants from the UK Biobank cohort were included. Self-reported oral health indicators (bleeding gums, painful gums, loose teeth) were surrogates for periodontitis at baseline. Systemic disease diagnoses and dates formed the process mining event log. Relative risk (RR) of systemic diseases, disease trajectories and Cox proportional hazard ratio (HR) models for mortality were compared to age and sex-matched controls who did not report history of periodontitis.
Results
Participants with loose teeth had shorter median time to most systemic diseases and crude RR were increased for several diseases including cardiovascular disease (crude RR: 1.15, 95% CI: 1.03–1.28), hypertension (crude RR: 1.14, 95% CI: 1.05–1.24) and depression (crude RR: 1.33, 95% CI: 1.09–1.61). Participants with loose teeth had increased RR for 20 disease trajectories, though these were not significant after adjustments. Participants with bleeding/painful gums had similar disease trajectories compared to matched controls.
Conclusions
Self-reported periodontitis may be associated with early and frequent multimorbidity development, though further evidence is required to confirm this hypothesis. People with periodontitis should be informed of the risks of disease progression and be targeted in prevention initiatives.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Protected by copyright. This is the peer reviewed version of the following article: Larvin, H., Kang, J., Aggarwal, V.R., Pavitt, S. and Wu, J. (2021), Multimorbid disease trajectories for people with periodontitis. J Clin Periodontol. 48( 12), 1587– 1596., which has been published in final form at https://doi.org/10.1111/jcpe.13536. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
Keywords: | Periodontitis, Tooth Loss, Noncommunicable Diseases, Multimorbidity, Cohort Studies |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Surgery (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Sep 2021 11:16 |
Last Modified: | 21 Dec 2022 13:49 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/jcpe.13536 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:177533 |
Commentary/Response Threads
- Larvin, H, Kang, J, Aggarwal, VR, Pavitt, S and Wu, J Multimorbid disease trajectories for people with periodontitis. (deposited 01 Sep 2021 11:16) [Currently Displayed]