Wang, Y, Shi, J and Tong, X (2021) Cross-talk Between Mechanosensitive Ion Channels and Calcium Regulatory Proteins in Cardiovascular Health and Disease. International Journal of Molecular Sciences, 22 (16). 8782. ISSN 1661-6596
Abstract
Mechanosensitive ion channels are widely expressed in the cardiovascular system. They translate mechanical forces including shear stress and stretch into biological signals. The most prominent biological signal through which the cardiovascular physiological activity is initiated or maintained are intracellular calcium ions (Ca2+). Growing evidence show that the Ca2+ entry mediated by mechanosensitive ion channels is also precisely regulated by a variety of key proteins which are distributed in the cell membrane or endoplasmic reticulum. Recent studies have revealed that mechanosensitive ion channels can even physically interact with Ca2+ regulatory proteins and these interactions have wide implications for physiology and pathophysiology. Therefore, this paper reviews the cross-talk between mechanosensitive ion channels and some key Ca2+ regulatory proteins in the maintenance of calcium homeostasis and its relevance to cardiovascular health and disease.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | mechanosensitive ion channels; Piezo channels; TRP channels; Ca2+; NCX; Orai; STIM; IP3R; SERCA; cardiovascular disease |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation FS/17/2/32559 |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Aug 2021 09:33 |
Last Modified: | 04 Sep 2023 15:49 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/ijms22168782 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:177106 |