Perez Hernandez, L, Hernandez Alvarez, A, Morgan, M et al. (2 more authors) (2021) Polyphenol bioaccessibility and anti-inflammatory activity of Mexican common beans (Phaseolus vulgaris L.) with diverse seed colour (Bioaccesibilidad y actividad antiinflamatoria de polifenoles de frijoles comunes mexicanos (Phaseolus vulgaris L.) con cascara de diferente color). CyTA - Journal of Food, 19 (1). pp. 682-690. ISSN 1947-6337
Abstract
Common bean consumption is associated with the prevention of chronic diseases and these effects are partially attributed to their polyphenol content. In this study, the bioaccessibility and anti-inflammatory activity of polyphenols from six Mexican cultivars of beans (Phaseolus vulgaris) varying in their seed colour, was evaluated. In all cultivars, digestion of starch and protein released significantly more polyphenols compared to soaking, cooking and methanol extraction. Pink cultivar ‘Marcela’ showed the highest total and bioaccessible polyphenol content (>50 mg GAE per gram dry bean). Black cultivar ‘Negro Jamapa’ showed a moderate anti-inflammatory effect, reducing mRNA levels of IL6, IL1β and iNOS by up to 20%. In contrast, cultivars ‘Marcela’ and yellow ‘Azufrado’ induced mRNA expression of IL1β, IL6, and HO-1, thus inducing both pro- and anti-oxidation pathways. Results indicate that enzymatic digestion promotes the bioaccessibility of common bean polyphenols and bean cultivars can elicit both anti- and pro-inflammatory responses in macrophages.
El consumo de frijol común está asociado con la prevención de enfermedades crónicas y estos efectos se atribuyen en parte a su contenido de polifenoles. En este estudio se evaluó la bioaccesibilidad y actividad antiinflamatoria de polifenoles de seis cultivares mexicanos de frijol (Phaseolus vulgaris) que varían en el color de las semillas. En todos los cultivares, la digestión de almidón y proteína liberó significativamente más polifenoles en comparación con el remojo, la cocción y la extracción con metanol. El cultivar rosado ‘Marcela’ mostró el mayor contenido de polifenoles totales y bioaccesibles (> 50 mg de GAE por gramo de frijol seco). El cultivar ‘Negro Jamapa’ mostró un efecto antiinflamatorio moderado, reduciendo los niveles de ARNm de IL6, IL1β e iNOS hasta en un 20%. En contraste, los cultivares ‘Marcela’ y amarillo ‘Azufrado’ indujeron la expresión de ARNm de IL1β, IL6 y HO-1, induciendo así vias pro- y anti-oxidativas. Los resultados indican que la digestión enzimática promueve la bioaccesibilidad de los polifenoles del frijol común y los cultivares de frijol pueden provocar respuestas tanto antiinflamatorias como proinflamatorias en macrófagos.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Beans; Phaseolus vulgaris; polyphenols; bioaccessibility; in vitro digestion; anti- inflammatory activity (Frijoles; Phaseolus vulgaris; polifenoles; bioaccesibilidad; digestión in vitro; actividad antiinflamatoria) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2021 11:29 |
Last Modified: | 17 Aug 2023 10:00 |
Published Version: | https://www.tandfonline.com/doi/full/10.1080/19476... |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/19476337.2021.1965660 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:177009 |