Smith, A.F., Thanarak, J., Pontin, M. et al. (2 more authors) (2021) Design and development of a robotic bioreactor for in vitro tissue engineering. In: Proceedings of 2021 IEEE International Conference on Robotics and Automation (ICRA 2021). IEEE International Conference on Robotics and Automation (ICRA 2021), 30 May - 05 Jun 2021, Xi’an, China. IEEE (Institute of Electrical and Electronics Engineers) , pp. 12428-12434.
Abstract
In this study, a novel robotic bioreactor is presented with capabilities of closed-loop control of force and displacement applied to a tissue scaffold and tissue scaffold stiffness calculation. These characteristics bring the potential of a robotic bioreactor that can optimize the mechanical properties of tissue constructs in order for them to match those of native tissues. Custom position and force control signals are designed to maintain a steady tensioning of the tissue scaffold while the latter one’s mechanical properties evolve in time. We propose a simple model to support the hypothesis that the stiffness of a cell-seeded scaffold increases over time, and thus force control signals need to be adjusted accordingly. The robotic bioreactor is able to measure the stiffness of a scaffold sample relatively accurately, with an average standard deviation of 0.2N/mm. The combination of accurate stiffness measurements and a closed-loop control system equips the robotic bioreactor with the fundamental requirements to achieve stiffness based force control in future in vitro experiments, and thus to a tissue-scaffold responsive technology for advanced tissue engineering.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Force measurement; Conferences; Biological system modeling; Tissue engineering; Force; Control systems; Force control |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Automatic Control and Systems Engineering (Sheffield) |
Funding Information: | Funder Grant number EPSRC Centre for Innovative Manufacturing in Large-Area Electronics N/A Engineering and Physical Science Research Council EP/S021035/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Jul 2021 08:44 |
Last Modified: | 18 Oct 2022 00:21 |
Status: | Published |
Publisher: | IEEE (Institute of Electrical and Electronics Engineers) |
Refereed: | Yes |
Identification Number: | 10.1109/ICRA48506.2021.9560728 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:176017 |