Lu, Zeye, Zheng, Qingshu, Zeng, Guangkuo et al. (3 more authors) (2021) Highly efficient NHC-iridium-catalyzed β-methylation of alcohols with methanol at low catalyst loadings. Science China Chemistry. pp. 1361-1366. ISSN 1674-7291
Abstract
The methylation of alcohols is of great importance since a broad number of bioactive and pharmaceutical alcohols contain methyl groups. Here, a highly efficient β-methylation of primary and secondary alcohols with methanol has been achieved by using bis-N-heterocyclic carbene iridium (bis-NHC-Ir) complexes. Broad substrate scope and up to quantitative yields were achieved at low catalyst loadings with only hydrogen and water as by-products. The protocol was readily extended to the β-alkylation of alcohols with several primary alcohols. Control experiments, along with DFT calculations and crystallographic studies, revealed that the ligand effect is critical to their excellent catalytic performance, shedding light on more challenging Guerbet reactions with simple alcohols.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Jul 2021 09:50 |
Last Modified: | 16 Oct 2024 17:41 |
Published Version: | https://doi.org/10.1007/s11426-021-1017-0 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1007/s11426-021-1017-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175979 |
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Description: Highly efficient NHC-iridium-catalyzed β-methylation of alcohols with methanol at low catalyst loadings