Ntostis, P, Swanson, G, Kokkali, G et al. (8 more authors) (2021) The effects of aging on molecular modulators of human embryo implantation. iScience, 24 (7). 102751. ISSN 2589-0042
Abstract
Advancing maternal reproductive age is accompanied by reduced fertility. As implantation rates decline during the normal maternal life-course, age-related, embryonic factors are altered and our inability to monitor these factors in an unbiased genome-wide manner in vivo, has severely limited our understanding of early human embryo development and implantation. Our high-throughput methodology uses trophectoderm samples representing the full spectrum of maternal reproductive ages with embryo implantation potential examined in relation to trophectoderm transcriptome dynamics and reproductive maternal age. Potential embryo-endometrial interactions were tested using trophectoderm sampled from young women, with the receptive uterine environment representing the most ‘fertile’ environment for successful embryo implantation. Potential roles for extracellular exosomes, embryonic metabolism and regulation of apoptosis were revealed. These biomarkers are consistent with embryo-endometrial crosstalk/developmental competency, serving as a mediator for successful implantation. Our data opens the door to developing a diagnostic test for predicting implantation success in women undergoing fertility treatment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Transcription; Gene expression; RNA sequencing; Trophectoderm; Human embryo development; Embryo implantation; Molecular biomarkers |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/K020501/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Jul 2021 10:44 |
Last Modified: | 25 Jun 2023 22:42 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.isci.2021.102751 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175775 |
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