Tanaka, M, Hayashi, M, Roach, L et al. (8 more authors) (2021) Synthesis of near-infrared absorbing triangular Au nanoplates using biomineralisation peptides. Acta Biomaterialia, 131. pp. 519-531. ISSN 1742-7061
Abstract
Triangular Au nanoplates (TrAuNPls) possessing strong plasmonic properties can be used as photothermal agents in cancer therapy. However, the controlled preparation of such morphologies typically requires harsh synthetic conditions. Biomolecules offer an alternative route to developing biocompatible synthetic protocols. In particular, peptides offer a novel route for inorganic synthesis under ambient conditions. Herein, using the previously isolated peptide, ASHQWAWKWE, for Au nanoparticle (AuNP) synthesis, the conditions for preparing TrAuNPls via a one-pot synthetic process of mixing HAuCl4 and peptides at room temperature were investigated to effectively obtain particles possessing near-infrared absorbance for non-invasive optical diagnosis and phototherapy. By adjusting the peptide concentration, the size and property of TrAuNPls were controlled under neutral pH conditions. The synthesised particles showed potential as photothermal therapeutic agents in vitro. In addition, peptide characterisation using B3 derivatives revealed the importance of the third amino acid histidine in morphological regulation and potential circular Au nanoplates (AuNPl) synthesis with ASEQWAWKWE and ASAQWAWKWE peptides. These findings provide not only an easy and green synthetic method for TrAuNPls and circular AuNPls, but also some insight to help elucidate the regulation of peptide-based nanoparticle synthesis for use in cancer therapy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. This is an author produced version of an article published in Acta Biomaterialia. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Gold nanoparticle; Mineralisation peptide; Photothermal therapy; Triangular nanoplate |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Jul 2021 09:03 |
Last Modified: | 28 Jun 2022 10:24 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.actbio.2021.06.010 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175754 |