Quintal‐Bojórquez, NDC, Carrillo‐Cocom, LM, Hernández‐Álvarez, AJ et al. (1 more author) (2021) Anticancer activity of protein fractions from chia (Salvia hispanica L.). Journal of Food Science. ISSN 0022-1147
Abstract
Salvia hispanica demonstrated to be a source of protein fractions with anticancer activity. The effect of the protein fractions <1, 1–3, and 3–5 kDa, obtained by ultrafiltration of the S. hispanica hydrolysate, was evaluated on the cellular viability of four cancer cell lines (MCF-7, Caco2, PC-3, and HepG2) and on human fibroblasts (hFB) at different concentrations (0.25, 0.5, 0.75, and 1 mg/ml). The protein fractions did not show cytotoxic effects on hFB. The protein fraction <1 kDa at 1 mg/ml showed the highest statistical effect on the cellular viability of all evaluated cancer lines; thus, its amino acid sequence was analyzed. From the multicriteria decision analysis of the peptide sequences obtained by mass spectrometry, the peptide KLKKNL with potential anticancer activity was selected. In conclusion, protein fractions could represent a therapeutic option for cancer treatment. However, further investigations are necessary to establish conclusive arguments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | amino acid sequence; anticancer activity; protein fractions; S. hispanica |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Jul 2021 11:19 |
Last Modified: | 01 Jul 2021 11:19 |
Status: | Published online |
Publisher: | Wiley |
Identification Number: | 10.1111/1750-3841.15780 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175748 |