Plant, AR, Larrieu, A orcid.org/0000-0002-9024-5348 and Causier, B orcid.org/0000-0001-5942-7031 (2021) Repressor for hire! The vital roles of TOPLESS‐mediated transcriptional repression in plants. New Phytologist. ISSN 0028-646X
Abstract
Transcriptional corepressors play important roles in establishing the appropriate levels of gene expression during growth and development. The TOPLESS (TPL) family of corepressors are critical for all plant life. TPLs are involved in numerous developmental processes and in the response to extrinsic challenges. As such these proteins have been the focus of intense study since Long and colleagues first described the TPL corepressor in 2006. In this review we will explore the evolutionary history of these essential plant-specific proteins, their mechanism of action based on recent structural analyses, and the myriad of pathways in which they function. We speculate how relatively minor changes in the peptide sequence of transcriptional regulators allowed them to recruit TPL into new processes, driving innovation and resulting in TPL becoming vital for plant development.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors New Phytologist © 2021 New Phytologist Foundation. This is the peer reviewed version of the following article: Plant, A.R., Larrieu, A. and Causier, B. (2021), Repressor for hire! The vital roles of TOPLESS-mediated transcriptional repression in plants. New Phytol. , which has been published in final form at https://doi.org/10.1111/nph.17428. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | adaptor proteins; Arabidopsis thaliana; corepressor; EAR motif; gene expression; hormone signalling; repression domain; TOPLESS (TPL) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Jun 2021 12:13 |
Last Modified: | 30 May 2022 00:38 |
Status: | Published online |
Publisher: | Wiley |
Identification Number: | 10.1111/nph.17428 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175622 |