Shandell, Mia Ann orcid.org/0000-0002-7864-758X, Lawrence, Samantha, Brackenbury, Will orcid.org/0000-0001-6882-3351 et al. (1 more author) (2019) Ionic modulation of immune checkpoint proteins. In: Physiology 2019, 07-10 Jul 2019, Aberdeen Conference Centre.
Abstract
Despite extensive basic and clinical research on immune checkpoint regulatory pathways, little is known about the effects of the ionic tumour microenvironment on immune checkpoint expression and function. We screened effects of ion channel modulating compounds on indoleamine-2',3'-dioxygenase (IDO1) activity. Here, we describe a mechanistic link between Na+/K+ ATPase inhibition by cardiac glycosides and activity of IDO1, a well-characterized immune checkpoint. IDO1 catalyses the rate-limitig step of tryptophan catabolim and inhibits the immune response to the tumour by local depletion of tryptophan, an amino acid essential for anabolic functions in cancer and T cells.
Metadata
Item Type: | Conference or Workshop Item |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL (MRC) UNSPECIFIED |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jun 2021 12:00 |
Last Modified: | 03 Nov 2024 01:06 |
Status: | Published |
Refereed: | Yes |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175570 |
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