Jones, F, Gamper, N orcid.org/0000-0001-5806-0207 and Gao, H (2021) Kv7 Channels and Excitability Disorders. In: Gamper, N and Wang, K, (eds.) Pharmacology of Potassium Channels. Handbook of Experimental Pharmacology, 267 . Springer , Cham, Switzerland , pp. 185-230. ISBN 978-3-030-84051-8
Abstract
Kv7.1-Kv7.5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major roles in neurons, muscle cells and epithelia where they underlie physiologically important K+ currents, such as neuronal M current and cardiac IKs. Specific biophysical properties of Kv7 channels make them particularly well placed to control the activity of excitable cells. Indeed, these channels often work as ‘excitability breaks’ and are targeted by various hormones and modulators to regulate cellular activity outputs. Genetic deficiencies in all five KCNQ genes result in human excitability disorders, including epilepsy, arrhythmias, deafness and some others. Not surprisingly, this channel family attracts considerable attention as potential drug targets. Here we will review biophysical properties and tissue expression profile of Kv7 channels, discuss recent advances in the understanding of their structure as well as their role in various neurological, cardiovascular and other diseases and pathologies. We will also consider a scope for therapeutic targeting of Kv7 channels for treatment of the above health conditions.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Keywords: | Channelopathy, Epilepsy, KCNQ, Kv7 channel, M current, Pain |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Sep 2021 14:27 |
Last Modified: | 08 Jun 2023 14:31 |
Published Version: | https://link.springer.com/chapter/10.1007%2F164_20... |
Status: | Published |
Publisher: | Springer |
Series Name: | Handbook of Experimental Pharmacology |
Identification Number: | 10.1007/164_2021_457 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175123 |