Johnston, J orcid.org/0000-0002-9928-989X (2021) Pharmacology of A-Type K+ Channels. In: Gamper, N and Wang, K, (eds.) Pharmacology of Potassium Channels. Handbook of Experimental Pharmacology, 267 . Springer , Cham, Switzerland , pp. 167-183. ISBN 978-3-030-84051-8
Abstract
Transient outward potassium currents were first described nearly 60 years ago, since then major strides have been made in understanding their molecular basis and physiological roles. From the large family of voltage-gated potassium channels members of 3 subfamilies can produce such fast-inactivating A-type potassium currents. Each subfamily gives rise to currents with distinct biophysical properties and pharmacological profiles and a simple workflow is provided to aid the identification of channels mediating A-type currents in native cells. Their unique properties and regulation enable A-type K+ channels to perform varied roles in excitable cells including repolarisation of the cardiac action potential, controlling spike and synaptic timing, regulating dendritic integration and long-term potentiation as well as being a locus of neural plasticity.
Metadata
Item Type: | Book Section |
---|---|
Authors/Creators: |
|
Editors: |
|
Copyright, Publisher and Additional Information: | © The Author(s), under exclusive license to Springer Nature Switzerland AG 2021. This is an author produced version of a book chapter published in Handbook of Experimental Pharmacology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | A-type K+ channel; Kv1.4; Kv3.4; Kv4; Potassium channel; Voltage-clamp |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Jun 2021 11:13 |
Last Modified: | 08 Jun 2023 21:54 |
Status: | Published |
Publisher: | Springer |
Series Name: | Handbook of Experimental Pharmacology |
Identification Number: | 10.1007/164_2021_456 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:175122 |