Maran, SR, Fleck, K, Monteiro-Teles, NM et al. (6 more authors) (2021) Protein acetylation in the critical biological processes in protozoan parasites. Trends in Parasitology, 37 (9). pp. 815-830. ISSN 1471-4922
Abstract
Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan parasites after the description of their acetylomes, indicating that acetylation might regulate crucial biological processes in these parasites. The demonstration that glycolytic enzymes are regulated by acetylation in protozoans shows that this modification might regulate several other processes implicated in parasite survival and adaptation during the life cycle, opening the chance to explore the regulatory acetylation machinery of these parasites as drug targets for new treatment development.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Elsevier Ltd. All rights reserved. This is an author produced version of an article published in Trends in Parasitology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Acetylation; acetylome; KATs; KDACs; bromodomain; glycolysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 May 2021 07:26 |
Last Modified: | 12 Jul 2022 13:30 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.pt.2021.04.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:174319 |
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