Campbell, TM, Trudel, G, Conaghan, P orcid.org/0000-0002-3478-5665 et al. (3 more authors) (2022) Flexion contracture is associated with knee joint degeneration on magnetic resonance imaging: data from the Osteoarthritis Initiative. Clinical and Experimental Rheumatology, 40 (5). 0993-0998. ISSN 0392-856X
Abstract
OBJECTIVES:
Knee osteoarthritis (OA) is often accompanied by a flexion contracture (FC), resulting in worse clinical outcomes. Our objective was to determine associations between knee FC and specific regional and/or structural alterations on magnetic resonance imaging (MRI) using the Osteoarthritis Initiative (OAI).
METHODS:
600 knees from the Foundation for the National Institutes of Health sub-study of the OAI were included. Knee extension was measured with a goniometer and FC was defined as inability to extend the knee to 0°. Structural alterations within the MRI Osteoarthritis Knee Score (MOAKS)-assessed regions that could potentially obstruct knee extension were primarily analysed. Multivariable linear regression models evaluated the effect size of MRI outcomes on knee extension.
RESULTS:
One-third (33.4%) of all participants had knee FC: 155 mild (1-5°, 26.0%), 44 moderate-severe (≥6°, 7.4%). Mean knee alignment was 0.3±3.7° valgus. Cartilage morphology and bone marrow lesion (BML) scores on the femoral side of the lateral patellofemoral joint were associated with lost knee extension (β=0.709, p<0.001, and β=0.666, p<0.001, respectively) as were higher osteophyte scores in multiple regions, worse meniscal score in the medial meniscal body (β=0.164, p<0.040) and posterior horn (β=0.400, p<0.001), and a worse effusion score (β=0.711, p<0.001).
CONCLUSIONS:
Knee flexion contractures were associated with non-specific, widespread MRI degenerative changes including cartilage loss and BMLs in the lateral patellofemoral joint, osteophytes, meniscal alterations and whole-joint effusion. Loss of knee extension in OA is likely a structurally-multifactorial outcome.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 May 2021 10:11 |
Last Modified: | 03 Mar 2023 16:29 |
Status: | Published |
Publisher: | Clinical and Experimental Rheumatology S.A.S. |
Identification Number: | 10.55563/clinexprheumatol/u8itzf |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:174283 |