Walker, IF, Khan, AM, Khan, AM et al. (4 more authors) (2018) Depression among multidrug-resistant tuberculosis patients in Punjab, Pakistan: a large cross-sectional study. The International Journal of Tuberculosis and Lung Disease, 22 (7). pp. 773-778. ISSN 1027-3719
Abstract
BACKGROUND AND OBJECTIVES: Depression is likely to be a factor in the low global rates of successful treatment for multidrug-resistant tuberculosis (MDR-TB) due to poor adherence to treatment. We aimed to estimate the prevalence of depression among patients being treated for MDR-TB in Pakistan, explore rates of depression over the course of treatment and identify risk factors for depression.
DESIGN: This cross-sectional study analysed health care service data from 12 treatment sites following a single screening event using the Patient Health Questionnaire 9 (PHQ-9). Logistic regression models were used to identify associations.
RESULTS: Data were collected from 1279 patients with MDR-TB. The proportion of MDR-TB patients with depression was 42.8% (95%CI 40.1–45.5). Rates of depression varied according to duration of treatment, with the highest proportion (53.2%) found in those who were in months 10–12 of treatment. The odds of depression in women were higher than for men (adjusted odds ratio [aOR] 1.84, 95%CI 1.46–2.33). The odds of depression were higher in patients living in concrete-built houses than in those living in mud-built houses (aOR 1.37, 95%CI 1.03–1.82).
CONCLUSION: Depression is common in MDR-TB patients, and should be screened for and treated within MDR-TB treatment programmes.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | depression; drug resistance; epidemiology; tuberculosis |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Nuffield Centre for International Health and Development (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 May 2021 15:53 |
Last Modified: | 24 May 2021 15:53 |
Status: | Published |
Publisher: | International Union Against Tuberculosis and Lung Disease |
Identification Number: | 10.5588/ijtld.17.0788 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:174277 |