Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

Rehling, D., Zhang, S.M., Jemth, A.-S. et al. (15 more authors) (2021) Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. Journal of Biological Chemistry, 296. 100568. ISSN 0021-9258

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Rehling, D.
  • Zhang, S.M.
  • Jemth, A.-S.
  • Koolmeister, T.
  • Throup, A.
  • Wallner, O.
  • Scaletti, E.
  • Moriyama, T.
  • Nishii, R.
  • Davies, J.
  • Desroses, M.
  • Rudd, S.G.
  • Scobie, M.
  • Homan, E.
  • Berglund, U.W.
  • Yang, J.J.
  • Helleday, T. ORCID logo https://orcid.org/0000-0002-7384-092X
  • Stenmark, P.
Copyright, Publisher and Additional Information:

© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords: NUDT15; NUDIX; hydrolase; MTH2; inhibitor; crystal structure
Dates:
  • Published: 19 March 2021
  • Published (online): 19 March 2021
  • Accepted: 19 March 2021
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 10 May 2021 11:42
Last Modified: 10 May 2021 11:42
Status: Published
Publisher: Elsevier BV
Refereed: Yes
Identification Number: 10.1016/j.jbc.2021.100568
Related URLs:
Open Archives Initiative ID (OAI ID):

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