Cosgrove, Jeremy, Hinder, Mark, St George, Rebecca et al. (5 more authors) (2021) Significant cognitive decline in Parkinson’s disease exacerbates the reliance on visual feedback during upper limb reaches. Neuropsychologia. 107885. ISSN 0028-3932
Abstract
While upper limb reaches are often made in a feed-forward manner, visual feedback during the movement can be used to guide the reaching hand towards a target. In Parkinson’s disease (PD), there is evidence that the utilisation of this visual feedback is increased. However, it is unclear if this is due solely to the characteristic slowness of movements in PD providing more opportunity for incorporating visual feedback to modify reach trajectories, or whether it is due to cognitive decline impacting (feed-forward) movement planning ability. To investigate this, we compared reaction times and movement times of reaches to a target in groups of PD patients with normal cognition (PD-NC), mild cognitive impairment (PD-MCI) or dementia (PD-D), to that of controls with normal cognition (CON-NC) or mild cognitive impairment (CON-MCI). Reaches were undertaken with full visual feedback (at a ‘natural’ and ‘fast-as-possible’ pace); with reduced visual feedback of the reaching limb to an illuminated target; and without any visual feedback to a remembered target with eyes closed. PD-D exhibited slower reaction times than all other groups across conditions, indicative of less efficient movement planning. When reaching to a remembered target with eyes closed, all PD groups exhibited slower movement times relative to their natural pace with full visual feedback. Crucially, this relative slowing was most pronounced for the PD-D group, compared to the PD-MCI and PD-NC groups, suggesting that substantial cognitive decline in PD exacerbates dependence on visual feedback during upper limb reaches.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Electronic Engineering (York) The University of York > Faculty of Sciences (York) > Computer Science (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 May 2021 08:30 |
Last Modified: | 08 Feb 2025 00:41 |
Published Version: | https://doi.org/10.1016/j.neuropsychologia.2021.10... |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.neuropsychologia.2021.107885 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:173739 |
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Description: Significant cognitive decline in Parkinson’s disease exacerbates the reliance on visual feedback during upper limb reaches -submitted manuscript
Licence: CC-BY-NC-ND 2.5