Gajjar, P, Nguyen, TTH orcid.org/0000-0002-6752-1455, Styliari, ID et al. (10 more authors) (2021) From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations. In: Respiratory Drug Delivery 2021. RDD 2021, 04-07 May 2021, Online. RDD Conference Series . RDD Online , pp. 87-98. ISBN 978-1-942911-55-5
Abstract
The design of a successful inhaled formulation is a complex project that requires fine tuning of processes and properties to achieve optimal performance. In this work we attempt to provide a summary from the INFORM2020 project of an all-inclusive investigation of inhalation powder blends at various levels of scrutiny. X-Ray Microscopy (XRM) is used to characterize the microstructure and the microstructural changes induced by processing, ring shear tests are used to assess the flowability of the powders and in silico molecular modeling is used to predict the morphology and inter-particle interactions that are critical to efficiently designing superior future formulations. Using this holistic characterization approach to link particle properties to successful inhaled therapies, we hope future dry powder inhalation formulation projects will leave the realm of mysterious art and become firmly science based.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 May 2021 15:17 |
Last Modified: | 15 May 2024 10:45 |
Published Version: | https://www.rddonline.com/rdd/article.php?id=0&sid... |
Status: | Published |
Publisher: | RDD Online |
Series Name: | RDD Conference Series |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:173530 |