Nguyen, TTH orcid.org/0000-0002-6752-1455, Turner, TD orcid.org/0000-0003-3776-2044, Matinong, AME et al. (3 more authors) (2021) Measured growth rates of Ibuprofen: comparing single crystal and bulk suspensions data. Chemical Engineering and Technology, 44 (7). pp. 1287-1293. ISSN 0930-7516
Abstract
Design of industrial crystallization processes usually employs laboratory‐scale experimental data which must be correlated with the full‐scale process for effective technology transfer. In this context, the measured growth rates of single crystals of Ibuprofen in stagnant ethanolic solutions are compared with data recorded for a population of crystals crystallized in an agitated 7ml reactor. The single crystal growth rates are found to be rather close to those determined in the agitated reactor, with both being also in good agreement with previously published data at the 750ml scale, suggesting that studies on single crystals can have utility for the purpose of crystallization process design and optimization.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Wiley‐VCH GmbH. This is the peer reviewed version of the following article:Nguyen, T.T.H., Turner, T.D., Matinong, A.M.E., Marziano, I., Hammond, R.B. and Roberts, K.J. (2021), Measured growth rates of Ibuprofen: comparing single crystal and bulk suspensions data. Chem. Eng. Technol.. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1002/ceat.202100025. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | Agitated batch crystallization; bulk suspension; growth rate; number-weighted mean diameter; single crystal growth |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number N8 Research (IKC only) M9044 EPSRC (Engineering and Physical Sciences Research Council) EP/I014446/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 May 2021 16:11 |
Last Modified: | 04 Jul 2022 16:14 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/ceat.202100025 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:173527 |