Byford, A orcid.org/0000-0002-3936-2688, Baird-Rayner, C and Forbes, K orcid.org/0000-0002-3745-1337 (2021) Don’t sugar coat it: the effects of gestational diabetes on the placental vasculature. The Biochemist, 43 (2). pp. 34-39. ISSN 0954-982X
Abstract
The placenta is a temporary organ, which facilitates the exchange of nutrients, waste and gases between the maternal and fetal circulatory systems. To perform its role, the placenta is a villous structure, which branches to cover a large surface area. In gestational diabetes (GDM), a major complication that affects otherwise healthy pregnancies, the placenta displays aberrant vasculature, including altered vascularization, villous immaturity, and endothelial dysfunction. Several contributors including reactive oxygen species (ROS), advanced glycation end products (AGEs) and the dysregulation of key angiogenic factors have been attributed to vascular dysfunction in GDM.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors. Published by Portland Press Limited under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/R023166/1 British Heart Foundation FS/19/59/34896 |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Apr 2021 13:31 |
Last Modified: | 26 Apr 2021 13:31 |
Status: | Published |
Publisher: | Biochemical Society |
Identification Number: | 10.1042/bio_2021_117 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:173168 |