Cui, Lixin, Zhang, Lichi, Bai, Lu et al. (2 more authors) (2021) Alzheimer's Brain Network Analysis Using Sparse Learning Feature Selection. In: Torsello, Andrea, Rossi, Luca, Pelillo, Marcello, Biggio, Battista and Robles-Kelly, Antonio, (eds.) Structural, Syntactic, and Statistical Pattern Recognition. Springer , Cham , pp. 184-194.
Abstract
Accurate identification of Mild Cognitive Impairment (MCI) based on resting-state functional Magnetic Resonance Imaging (RS-fMRI) is crucial for reducing the risk of developing Alzheimer's disease (AD). In the literature, functional connectivity (FC) is often used to extract brain network features. However, it still remains challenging for the estimation of FC because RS-fMRI data are often high-dimensional and small in sample size. Although various Lasso-type sparse learning feature selection methods have been adopted to identify the most discriminative features for brain disease diagnosis, they suffer from two common drawbacks. First, Lasso is instable and not very satisfactory for the high-dimensional and small sample size problem. Second, existing Lasso-type feature selection methods have not simultaneously encapsulate the joint correlations between pairwise features and the target, the correlations between pairwise features, and the joint feature interaction into the feature selection process, thus may lead to suboptimal solutions. To overcome these issues, we propose a novel sparse learning feature selection method for MCI classification in this work. It unifies the above measures into a minimization problem associated with a least square error and an Elastic Net regularizer. Experimental results demonstrate that the diagnosis accuracy for MCI subjects can be significantly improved using our proposed feature selection method.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Computer Science (York) |
Depositing User: | Pure (York) |
Date Deposited: | 15 Apr 2021 09:50 |
Last Modified: | 16 Oct 2024 11:12 |
Status: | Published |
Publisher: | Springer |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:173117 |
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