Henderson, PJF orcid.org/0000-0002-9187-0938, Maher, C, Elbourne, LDH et al. (3 more authors) (2021) Physiological Functions of Bacterial “Multidrug” Efflux Pumps. Chemical Reviews. ISSN 0009-2665
Abstract
Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections. However, it is increasingly realized that many, probably most, such pumps have physiological roles that are distinct from protection of bacteria against antimicrobials administered by humans. Here we undertake a broad survey of the proteins involved, allied to detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with the experimental strategies that enable rapid and economical progress in understanding their true physiological roles. Once these roles are established, the knowledge can be harnessed to design more effective drugs, improve existing microbial production of drugs for clinical practice and of feedstocks for commercial exploitation, and even develop more sustainable biological processes that avoid, for example, utilization of petroleum.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 American Chemical Society. This is an author produced version of an article published in Chemical Reviews. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Apr 2021 11:17 |
Last Modified: | 24 Mar 2022 01:38 |
Status: | Published online |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.chemrev.0c01226 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:172741 |