Afanasenkau, D., Kalinina, D., Lyakhovetskii, V. et al. (8 more authors) (2020) Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature Biomedical Engineering, 4 (10). pp. 1010-1022. ISSN 2157-846X
Abstract
Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s), under exclusive licence to Springer Nature Limited 2020. This is an author-produced version of a paper subsequently published in Nature Biomedical Engineering. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Automatic Control and Systems Engineering (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - HORIZON 2020 804005 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Mar 2021 14:32 |
Last Modified: | 26 Mar 2021 14:51 |
Status: | Published |
Publisher: | Nature Research |
Refereed: | Yes |
Identification Number: | 10.1038/s41551-020-00615-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:172590 |