Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

McNae, Iain W, Kinkead, James, Malik, Divya et al. (19 more authors) (2021) Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature Communications. 1052. ISSN 2041-1723

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • McNae, Iain W
  • Kinkead, James
  • Malik, Divya
  • Yen, Li-Hsuan
  • Walker, Martin K (mw552@york.ac.uk)
  • Swain, Chris
  • Webster, Scott P
  • Gray, Nick
  • Fernandes, Peter M
  • Myburgh, Elmarie ORCID logo https://orcid.org/0000-0002-2007-5902
  • Blackburn, Elizabeth A
  • Ritchie, Ryan
  • Austin, Carol
  • Wear, Martin A
  • Highton, Adrian J
  • Keats, Andrew J
  • Vong, Antonio
  • Dornan, Jacqueline
  • Mottram, Jeremy C ORCID logo https://orcid.org/0000-0001-5574-3766
  • Michels, Paul A M
  • Pettit, Simon
  • Walkinshaw, Malcolm D
Copyright, Publisher and Additional Information:

© The Author(s) 2021

Keywords: Acute Disease,Allosteric Regulation/drug effects,Animals,Glycolysis/drug effects,Hep G2 Cells,Humans,Inhibitory Concentration 50,Kaplan-Meier Estimate,Mice,Parasites/drug effects,Phosphofructokinases/antagonists & inhibitors,Protein Binding/drug effects,Protein Kinase Inhibitors/chemistry,Protein Multimerization,Structure-Activity Relationship,Trypanosoma/drug effects,Trypanosomiasis, African/drug therapy
Dates:
  • Published: 16 February 2021
  • Accepted: 11 January 2021
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Chemistry (York)
The University of York > Faculty of Sciences (York) > Hull York Medical School (York)
The University of York > Faculty of Sciences (York) > Biology (York)
Depositing User: Pure (York)
Date Deposited: 23 Mar 2021 16:10
Last Modified: 21 Jan 2025 17:52
Published Version: https://doi.org/10.1038/s41467-021-21273-6
Status: Published
Refereed: Yes
Identification Number: 10.1038/s41467-021-21273-6
Open Archives Initiative ID (OAI ID):

Download

Filename: s41467_021_21273_6.pdf

Description: s41467-021-21273-6

Licence: CC-BY 2.5

Export

Statistics