The use of yttrium in medical imaging and therapy:historical background and future perspectives

Abstract

Yttrium is a chemically versatile rare earth element that finds use in a range of applications including lasers and superconductors. In medicine, yttrium-based materials are used in medical lasers and biomedical implants. This is extended through the array of available yttrium isotopes to enable roles for 90Y complexes as radiopharmaceuticals and 86Y tracers for positron emission tomography (PET) imaging. The naturally abundant isotope 89Y is proving to be suitable for nuclear magnetic resonance investigations, where initial reports in the emerging field of hyperpolarised magnetic resonance imaging (MRI) are promising. In this review we explore the coordination and radiochemical properties of yttrium, and its role in drugs for radiotherapy, PET imaging agents and perspectives for applications in hyperpolarised MRI. This journal is

Metadata

Item Type:	Article
Authors/Creators:	Tickner, Ben J. Stasiuk, Graeme J. Duckett, Simon B. https://orcid.org/0000-0002-9788-6615 Angelovski, Goran
Copyright, Publisher and Additional Information:	© The Royal Society of Chemistry 2020. Funding Information: We would like to thank Prof. Simon Cotton for help in obtaining the literature on lanthanide and actinide chemistry and Prof. Gyula Tirsco for helpful discussions on kinetic inertness. B. J. T. would like to thank the Wild Overseas Scholar’s Fund (University of York) for financial support. G. J. S. would like to thank the MRC for funding (MR/T002573/1). Open Access funding provided by the Max Planck Society.
Dates:	Published (online): 23 July 2020 Published: 7 September 2020
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Chemistry (York)
Depositing User:	Pure (York)
Date Deposited:	12 Mar 2021 11:10
Last Modified:	08 Apr 2025 23:16
Published Version:	https://doi.org/10.1039/c9cs00840c
Status:	Published
Refereed:	Yes
Identification Number:	10.1039/c9cs00840c
Related URLs:	http://www.scopus.com/inward/record.url?...
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:172130

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The use of yttrium in medical imaging and therapy:historical background and future perspectives

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