Rayner, Peter John orcid.org/0000-0002-6577-4117, Burns, Michael orcid.org/0000-0002-5569-1270, Fear, Elizabeth et al. (1 more author) (2021) Steric and Electronic Effects on the 1H Hyperpolarisation of Substituted Pyridazines by Signal Amplification by Reversible Exchange. MAGNETIC RESONANCE IN CHEMISTRY. pp. 1187-1198. ISSN 0749-1581
Abstract
Utility of the pyridazine motif is growing in popularity as pharmaceutical and agrochemical agents. The detection and structural characterisation of such materials is therefore imperative for the successful development of new products. Signal Amplification by Reversible Exchange (SABRE) offers a route to dramatically improve the sensitivity of magnetic resonance methods and we apply it here to the rapid and cost effective hyperpolarisation of substituted pyridazines. The 33 substrates investigated cover a range of steric and electronic properties and their capacity to perform highly effective SABRE to be assessed. We find the method to be tolerant to a broad range of electron donating and withdrawing groups, however, sensitivity is evident when steric bulk is added to the 3 and 6-positions of the pyridazine ring. We optimise the method by reference to a disubstituted ester that yields signal gains of >9 000-fold at 9.4 T (>28% spin polarisation).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z EPSRC EP/R51181X/1 |
Depositing User: | Pure (York) |
Date Deposited: | 12 Mar 2021 10:00 |
Last Modified: | 26 Nov 2024 00:49 |
Published Version: | https://doi.org/10.1002/mrc.5152 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/mrc.5152 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:172122 |
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Description: Steric and electronic effects on the1H hyperpolarisation ofsubstituted pyridazines by signal amplification by reversibleexchange
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