Roach, L orcid.org/0000-0002-9166-6662, Booth, ME orcid.org/0000-0001-5466-6447, Ingram, N orcid.org/0000-0001-5274-8502 et al. (7 more authors) (2021) Evaluating Phospholipid-Functionalized Gold Nanorods for In Vivo Applications. Small, 17 (13). 2006797. ISSN 1613-6810
Abstract
Gold nanorods (AuNRs) have attracted a great deal of attention due to their potential for use in a wide range of biomedical applications. However, their production typically requires the use of the relatively toxic cationic surfactant cetyltrimethylammonium bromide (CTAB) leading to continued demand for protocols to detoxify them for in vivo applications. In this study, a robust and facile protocol for the displacement of CTAB from the surface of AuNRs using phospholipids is presented. After the displacement, CTAB is not detectable by NMR spectroscopy, surface-enhanced Raman spectroscopy, or using pH-dependent ζ-potential measurements. The phospholipid functionalized AuNRs demonstrated superior stability and biocompatibility (IC₅₀ > 200 µg mL¯¹) compared to both CTAB and polyelectrolyte functionalized AuNRs and are well tolerated in vivo. Furthermore, they have high near-infrared (NIR) absorbance and produce large amounts of heat under NIR illumination, hence such particles are well suited for plasmonic medical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | biocompatibility; gold nanorods; in vivo; phospholipids; stability |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics |
Funding Information: | Funder Grant number MRC (Medical Research Council) MC_PC_14109 Royal Society IEC\R3\170038 EPSRC (Engineering and Physical Sciences Research Council) EP/T013753/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Mar 2021 12:37 |
Last Modified: | 08 Jan 2025 14:34 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/smll.202006797 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:171965 |