Chan, H.-F. orcid.org/0000-0002-5382-2097, Collier, G. orcid.org/0000-0002-1874-4775, Parra-Robles, J. et al. (1 more author) (2021) Finite element simulations of hyperpolarized gas DWI in micro‐CT meshes of acinar airways: validating the cylinder and stretched exponential models of lung microstructural length scales. Magnetic Resonance in Medicine, 86 (1). pp. 514-525. ISSN 0740-3194
Abstract
Purpose
This work assesses the accuracy of the stretched exponential (SEM) and cylinder models of lung microstructural length scales that can be derived from hyperpolarized gas DWI. This was achieved by simulating 3He and 129Xe DWI signals within two micro‐CT–derived realistic acinar airspace meshes that represent healthy and idiopathic pulmonary fibrosis lungs.
Methods
The healthy and idiopathic pulmonary fibrosis acinar airway meshes were derived from segmentations of 3D micro‐CT images of excised human lungs and meshed for finite element simulations of the Bloch‐Torrey equations. 3He and 129Xe multiple b value DWI experiments across a range of diffusion times (3He Δ = 1.6 ms; 129Xe Δ = 5 to 20 ms) were simulated in each mesh. Global SEM mean diffusive length scale and cylinder model mean chord length value was derived from each finite element simulation and compared against each mesh’s mean linear intercept length, calculated from intercept length measurements within micro‐CT segmentation masks.
Results
The SEM‐derived mean diffusive length scale was within ±10% of the mean linear intercept length for simulations with both 3He (Δ = 1.6 ms) and 129Xe (Δ = 7 to 13 ms) in the healthy mesh, and with 129Xe (Δ = 13 to 20 ms) for the idiopathic pulmonary fibrosis mesh, whereas for the cylinder model–derived mean chord length the closest agreement with mean linear intercept length (11.7% and 22.6% difference) was at 129Xe Δ = 20 ms for both healthy and IPF meshes, respectively.
Conclusion
This work validates the use of the SEM for accurate estimation of acinar dimensions and indicates that the SEM is relatively robust across a range of experimental conditions and acinar length scales.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | cylinder airway model; finite element simulations; hyperpolarized gas DWI; lung morphometry; micro‐CT; stretched exponential model |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/M008894/1 NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Mar 2021 14:08 |
Last Modified: | 15 Feb 2022 14:50 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.28703 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:171703 |