Cousins, D.L., Fricero, P., Kopf, K.P.M. et al. (4 more authors) (2021) Pyrimidin‐6‐yl trifluoroborate salts as versatile templates for heterocycle synthesis. Angewandte Chemie International Edition, 60 (17). pp. 9412-9415. ISSN 1433-7851
Abstract
We report a novel and general method to access a highly under‐studied privileged scaffold – pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chemistry is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C‐B bond when suitably activated.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | pyrimidine; trifluoroborate; chemoselective; cross-coupling |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 COSSHNET - 606734 EUROPEAN COMMISSION - HORIZON 2020 721223 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Feb 2021 16:38 |
Last Modified: | 10 Feb 2022 14:21 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.202101297 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:171513 |