Rajkumar, A.D., Reynolds, G.K., Wilson, D. et al. (2 more authors) (2019) The effect of roller compaction and tableting stresses on pharmaceutical tablet performance. Powder Technology, 341. pp. 23-37. ISSN 0032-5910
Abstract
In this research the effect of two fundamental stresses, i.e. the tableting load and roller compaction pressure, on tablet disintegration were investigated. Excipient materials were roller compacted using a range of pressures, and tablets were produced by compressing the consequent granules at varying tableting loads. For this study mannitol, a brittle and soluble material, and microcrystalline cellulose, a deformable and insoluble material, were investigated at varying binary ratios. The tablets were characterised by analysis of the compactibility and a flow cell imaging method was utilised to investigate tablet disintegration in real-time. It was found that the effect of roller compaction (RC) pressure on tablet tensile strength and porosity was dependent on the tableting load used. At low tableting load, the tablet porosity varied depending on the RC pressure used, whereas the tensile strength was largely unaffected. The use of a high tableting load leads to the opposite effect being observed. The tensile strength was highly dependent on the RC pressure used. In terms of the tablet disintegration the RC pressure did not influence the disintegration behaviour when low tableting loads were used as the process was rapid. When higher tableting loads were used, tablets containing granules roller compacted using lower pressure expanded in size larger than when a low RC pressure was used. A low RC pressure also lead to a faster particle release rate was observed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Published by Elsevier B.V. |
Keywords: | Roller compaction; Tableting; Compactibility; Disintegration |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Feb 2021 09:16 |
Last Modified: | 17 Feb 2021 09:16 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.powtec.2018.08.065 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:171200 |