Razaghi, H., Saatchi, R., Bishop, N.J. et al. (2 more authors) (2020) Evaluation of vibration analysis to assess bone mineral density in children. WSEAS Transactions on Biology and Biomedicine, 17. pp. 39-47. ISSN 1109-9518
Abstract
The effectiveness of vibration analysis to assess bone mineral density (BMD) in children with suspected reduction in bone density was studied. A system was designed that measured the ulna's vibration responses in vivo. The system was evaluated on the ulnae of 48 children (mean age=12.0, std=3.5 years), 31 of whom had been confirmed to have osteogenesis imperfecta (OI). All children had dual energy X-ray absorptiometry (DXA) scan as part of their routine clinical care and vibration analysis was performed on the same day. Frequency spectra of the ulnae's vibration responses were obtained and processed by principal component analysis. Four main principal components were selected and together with age, sex and right hand ulna's length were used in a regression analysis to estimate BMD. Regression analysis was repeated using the children's leave-one-out and partitioning methods. The percentage similarity and correlation between the DXA-derived and vibration analysis estimated BMDs using the leave-one-out were 80.34% and 0.59 and for partitioning were 74.2% and 0.64 respectively. There was correlation between vibration analysis BMD readings and those derived from DXA however a larger study will be needed to better establish the extent to which vibration analysis can assist in assessing bone density in clinical environments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 World Scientific and Engineering Academy and Society (WSEAS). This is an author-produced version of a paper subsequently published in WSEAS Transactions on Biology and Biomedicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone mineral density; Vibration analysis; Osteogenesis imperfecta |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Feb 2021 12:04 |
Last Modified: | 12 Feb 2021 12:08 |
Status: | Published |
Publisher: | World Scientific and Engineering Academy and Society |
Refereed: | Yes |
Identification Number: | 10.37394/23208.2020.17.6 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:171057 |