Lynch, H.F., Darton, T.C. orcid.org/0000-0003-2209-9956, Levy, J. et al. (7 more authors) (2021) Promoting ethical payment in human infection challenge studies. The American Journal of Bioethics, 21 (3). pp. 11-31. ISSN 1526-5161
Abstract
To prepare for potential human infection challenge studies (HICS) involving SARS-CoV-2, we convened a multidisciplinary working group to address ethical questions regarding whether and how much SARS-CoV-2 HICS participants should be paid. Because the goals of paying HICS participants, as well as the relevant ethical concerns, are the same as those arising for other types of clinical research, the same basic framework for ethical payment can apply. This framework divides payment into reimbursement, compensation, and incentives, focusing on fairness and promoting adequate recruitment and retention as counterweights to concerns about undue inducement. Within the basic framework, several factors are especially salient for HICS, and for SARS-CoV-2 HICS in particular, including the nature of participant confinement, anticipated discomfort, risks and uncertainty, participant motivations, and trust. These factors are reflected in a payment worksheet created to help sponsors, researchers, and ethics reviewers systematically develop and assess ethically justifiable payment amounts.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Taylor & Francis Group, LLC. This is an author-produced version of a paper subsequently published in American Journal of Bioethics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | COVID-19; Challenge study; SARS-CoV-2; payment |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Feb 2021 14:27 |
Last Modified: | 16 Feb 2022 17:30 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/15265161.2020.1854368 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170972 |