Akpeimeh, GF orcid.org/0000-0003-1543-5747, Fletcher, LA, Evans, BE orcid.org/0000-0001-9815-3141 et al. (1 more author) (2021) Quantitative microbial risk assessment (QMRA) of workers exposure to bioaerosols at MSW open dumpsites. Risk Analysis, 41 (10). pp. 1911-1924. ISSN 0272-4332
Abstract
The bioaerosol exposure data from the study by Akpeimeh, Fletcher, and Evans (2019) was used to compute the risk of infection from the exposure of dumpsite workers to Aspergillus fumigatus and Escherichia coli O157:H7. A stochastic (Markov Chain) model was used to model the transport of the inhaled dose though the human respiratory system and then integrated into the beta‐Poisson dose–response model to estimate workers risks of respiratory and gastrointestinal (GI) infection. The infection risk was computed based on workers exposure to E. coli O157:H7 at 10–50% pathogen ingestion rate and pathogen‐indicator ratio (P:I) of 1:103 and 1:104, while exposure to A. fumigatus was based solely on the average initial exposure dose. The results showed that after 11 hours of exposure, workers engaged in scavenging, waste sorting, and site monitoring were at risk of respiratory and GI infection in the magnitude of 10−1. However, the risk estimates associated with specific areas of the dumpsite showed that, the risk of GI infection at the active area ranged between 3.23 × 10−3–1.56 × 10−2 and 3.25 × 10−4–1.62 × 10−3; dormant area 2.06 × 10−3–1.01 × 10−2 and 2.09 × 10−4–1.04 × 10−3; entrance 1.85 × 10−3–9.09 × 10−3 and 1.87 × 10−4–9.27 × 10−4; boundary 1.82 × 10−3–8.82 × 10−3 and 2.09 × 10−4–8.94 × 10−4 for P:I = 1:103 and 1:104 respectively, while the risk of respiratory infection risks were in the magnitude of 10−1 for all four locations. The estimated risk of workers developing respiratory and gastrointestinal infections were high for all activities assessed at the dumpsite.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 Society for Risk Analysis. This is the peer reviewed version of the following article: Akpeimeh, GF , Fletcher, LA, Evans, BE et al. (1 more author) (2021) Quantitative microbial risk assessment (QMRA) of workers exposure to bioaerosols at MSW open dumpsites. Risk Analysis, 41 (10). pp. 1911-1924. ISSN 0272-4332, which has been published in final form at http://doi.org/10.1111/risa.13670. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | Aspergillus fumigatus; bioaerosols; E. coli; open dumpsite; QMRA |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Civil Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Feb 2021 16:21 |
Last Modified: | 31 Dec 2022 01:13 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/risa.13670 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170717 |