Rubens, R.D., Tinson, C.L., Coleman, R.E. orcid.org/0000-0002-4275-1043 et al. (4 more authors) (1988) Prednisolone improves the response to primary endocrine treatment for advanced breast cancer. British Journal of Cancer, 58 (5). pp. 626-630. ISSN 0007-0920
Abstract
Two hundred and twenty patients with progressive advanced breast cancer were given primary endocrine treatment (PET) according to menstrual status. Pre-menopausal patients received ovarian irradiation (O) and post-menopausal tamoxifen 10 mg bd (T). Patients were randomised to receive either no additional treatment or prednisolone 5 mg bd (P). Similar results were observed in each menstrual subgroup. In 194 evaluable patients, the response to PET + P was 49% and to PET alone 30% (P less than 0.01). P increased the median duration of response from 9 to 14 months (P less than 0.002) and the median time to disease progression from 5 to 9 months (P less than 0.001). Response to P after O or T alone occurred in only 2/62 (3%). Median survival in patients randomised to receive P at the outset of PET was prolonged by 4 months (P less than 0.05). The addition of P significantly improves the response to O or T in the treatment of advanced breast cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1988 The Macmillan Press Ltd. |
Keywords: | Adult; Breast Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Humans; Menopause; Middle Aged; Ovary; Prednisolone; Tamoxifen |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Feb 2021 12:07 |
Last Modified: | 15 Feb 2021 12:07 |
Status: | Published |
Publisher: | Springer Nature (for Cancer Research UK) |
Refereed: | Yes |
Identification Number: | 10.1038/bjc.1988.273 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170589 |