Williams, E.J., Mair, L., de Silva, T.I. orcid.org/0000-0002-6498-9212 et al. (7 more authors) (2021) Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study. Journal of Hospital Infection, 110. pp. 103-107. ISSN 0195-6701
Abstract
It can be a diagnostic challenge to identify COVID-19 patients in whom antibiotics can be safely withheld. We evaluate the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with a low serum procalcitonin (PCT), defined as ≤0.25ng/ml. Results showed reduced antibiotic consumption in this patient group, without increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission for those with a negative PCT. Our results suggest effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for procalcitonin in this setting.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an author produced version of a paper subsequently published in Journal of Hospital Infection. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Antimicrobial stewardship; COVID-19; Procalcitonin; SARS-CoV-2; bacterial co-infection; superadded infection |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Jan 2021 14:14 |
Last Modified: | 11 Feb 2022 17:00 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.jhin.2021.01.006 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170565 |