Quattrini, Luca, Sadiq, Maria, Petrarolo, Giovanni et al. (4 more authors) (2020) Aldehyde Dehydrogenases and Prostate Cancer:Shedding Light on Isoform Distribution to Reveal Druggable Target. Biomedicines. 569. ISSN 2227-9059
Abstract
Prostate cancer represents the most common malignancy diagnosed in men, and is the second-leading cause of cancer death in this population. In spite of dedicated efforts, the current therapies are rarely curative, requiring the development of novel approaches based on innovative molecular targets. In this work, we validated aldehyde dehydrogenase 1A1 and 1A3 isoform expressions in different prostatic tissue-derived cell lines (normal, benign and malignant) and patient-derived primary prostate tumor epithelial cells, demonstrating their potential for therapeutic intervention using a small library of aldehyde dehydrogenase inhibitors. Compound 3b, 6-(4-fluorophenyl)-2-phenylimidazo [1,2-a]pyridine exhibited not only antiproliferative activity in the nanomolar range against the P4E6 cell line, derived from localized prostate cancer, and PC3 cell lines, derived from prostate cancer bone metastasis, but also inhibitory efficacy against PC3 colony-forming efficiency. Considering its concomitant reduced activity against normal prostate cells, 3b has the potential as a lead compound to treat prostate cancer by means of a still untapped molecular target.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 by the authors. |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) > Yorkshire Cancer Research Unit (York) |
Depositing User: | Pure (York) |
Date Deposited: | 25 Jan 2021 12:40 |
Last Modified: | 23 Jan 2025 00:24 |
Published Version: | https://doi.org/10.3390/biomedicines8120569 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3390/biomedicines8120569 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170432 |