Duffy, J.M.N., Cairns, A.E., Magee, L.A. et al. (16 more authors) (2020) Standardising definitions for the pre-eclampsia core outcome set: A consensus development study. Pregnancy Hypertension, 21. pp. 208-217. ISSN 2210-7789
Abstract
Objectives
To develop consensus definitions for the core outcome set for pre-eclampsia.
Study design
Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group.
Results
Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring.
Conclusions
Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. This is an author produced version of a paper subsequently published in Pregnancy Hypertension. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Consensus development study; Core outcome set; Hypertension in pregnancy; Outcome measure; Pre-eclampsia; Randomised controlled trials |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Jan 2021 17:23 |
Last Modified: | 20 Jun 2021 00:38 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.preghy.2020.06.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:170024 |
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Filename: Standardising definitions for the pre-eclampsia core outcome set 8 June 2019 MJW.pdf
Licence: CC-BY-NC-ND 4.0