Milescu, Roxana Alina, Segatto, Mateus Lodi, Stahl, Aylon et al. (4 more authors) (2020) Sustainable Single-Stage Solid-Liquid Extraction of Hesperidin and Rutin from Agro-Products Using Cyrene. ACS Sustainable Chemistry and Engineering. 18245–18257. ISSN 2168-0485
Abstract
Hesperidin and rutin are two sought-after natural flavonoids, traditionally extracted from abundant natural citrus fruits and tea leaves using large amounts of ethanol or methanol solvents. Recent trends in extractions have focused on minimizing the use of solvents and creating simpler cost-effective processes. This study aims to apply the concept of chemical valorization in the context of a circular economy, by using agro-industrial waste and biobased alternatives to traditional solvents, which are of environmental concern. We use minimum amounts of solvent/sample (5 mL/0.25 or 0.5 g) to extract hesperidin and rutin in a single-stage solid-liquid extraction. Thirty individual solvents and HSPiP were applied to find the best solvents/blends for extraction. The type of solvent, sample preparation, maceration time, and extraction temperature were studied. Results showed that the biobased solvent Cyrene is very effective when mildly heated to 65 °C (up to 91%) or mixed with water. Adding water to Cyrene forms its geminal diol hydrate, this enhances the solubility and extraction of hesperidin and rutin up to ten times than those of the original pure ketone form. Quantitative sustainability metrics from the CHEM21 Toolkit demonstrated that our extraction methodology is environmentally friendly and offers future potential of isolation of other flavonoids.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | circular economy,Cyrene,green chemistry,solid-liquid extraction,sustainable chemistry,sustainable extraction |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 Jan 2021 14:30 |
Last Modified: | 16 Oct 2024 17:13 |
Published Version: | https://doi.org/10.1021/acssuschemeng.0c06751 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1021/acssuschemeng.0c06751 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:169659 |
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