Rodgers, G., Wilson, E.J., Robertson, C.C. orcid.org/0000-0002-1419-9618 et al. (2 more authors) (2021) Synthesis of boronic ester γ‐lactam building blocks. Advanced Synthesis & Catalysis, 363 (9). pp. 2392-2395. ISSN 1615-4150
Abstract
Saturated heterocycles are found widely in biologically active compounds such as medicinal drugs and agrochemicals. However, boronic acid‐derived building blocks for these structures have limited availability, particularly in comparison to heteroaromatic boronic acids. We report the preparation of boronic ester γ‐lactams through a Cu‐catalysed conjugate borylation‐cyclisation protocol. Using a chiral catalyst, this can be performed in high enantioselectivity. Exploration of the further transformations of these reagents suggest that the boronic esters have much potential as chemical building blocks.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 The Authors. Advanced Synthesis & Catalysis Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | boron; lactams; copper; building blocks; cross-coupling |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/T009292/1 Engineering and Physical Sciences Research Council 1965899 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Feb 2021 13:51 |
Last Modified: | 01 Feb 2022 10:31 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/adsc.202001339 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:169069 |