Harrity, J.P.A. orcid.org/0000-0001-5038-5699, Mora-Radó, H., Czechtizky, W. et al. (1 more author) (2021) Design and synthesis of fused pyridine building blocks for automated library generation. ChemMedChem, 16 (2). pp. 328-334. ISSN 1860-7179
Abstract
We demonstrate that a diboration‐electrocyclization sequence provides access to a range of pyridine fused small molecule boronic ester building blocks, and that these are amenable to high throughput synthesis leading to biaryl and ether linked compound libraries. Moreover, the implementation of an integrated physchem and ADME profiling workflow allows accelerated design of novel lead compounds for application in drug discovery projects.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Wiley‐VCH GmbH. This is an author-produced version of a paper subsequently published in ChemMedChem. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | ADME; boron; compound libraries; physicochemical; pyridines |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number European Commission - FP6/FP7 COSSHNET - 606734 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Dec 2020 10:11 |
Last Modified: | 02 Feb 2022 08:52 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/cmdc.202000852 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168909 |