Kaskiewicz, PL orcid.org/0000-0001-6708-6687, Turner, TD, Warren, NJ orcid.org/0000-0002-8298-1417 et al. (4 more authors) (2020) Isothermal by Design: Comparison with an Established Isothermal Nucleation Kinetics Analysis Method. Chemical Engineering & Technology, 43 (10). pp. 1971-1980. ISSN 0930-7516
Abstract
The nucleation kinetics of the alpha form of p‐aminobenzoic acid from ethanolic and aqueous solutions is examined through a comparative examination of temperature‐jump and anti‐solvent drown‐out isothermal crystallization methodologies. Analysis of the data reveals the measured induction times, and the calculated effective interfacial tensions as a function of the supersaturation show broadly equivalent behavior for the aqueous‐ethanol mixed‐solvent drown‐out and temperature‐jump ethanol solution systems, confirming the comparability of the two methodologies. The results also demonstrate poorer agreement with the temperature‐jump pure aqueous system, highlighting the importance of the strength of solvation/desolvation as the key rate‐limiting process for the overall nucleation behavior.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Wiley‐VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Antisolvent crystallization; Induction time; Isothermal; Kinetics; Nucleation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Dec 2020 11:13 |
Last Modified: | 09 Dec 2020 11:13 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/ceat.202000113 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168809 |