Kwan, MHT, Pokar, NPB, Good, C et al. (4 more authors) (2020) Deactivation Mechanisms of Iodo-Iridium Catalysts in Chiral Amine Racemization. Tetrahedron. 131823. p. 131823. ISSN 0040-4020
Abstract
The homogenous, [IrCp*I2]2, SCRAM catalyst (1) is active in the racemization of chiral amines. NMR, kinetic and structural mechanistic studies have determined the cause of catalyst deactivation to occur when ammonia or methylamine are liberated by hydrolysis or aminolysis of the intermediate imine, which tightly coordinate to the iridium centre to block turnover. Control of moisture and substrate concentration can suppress deactivation, whilst partial reactivation of spent catalyst was identified using hydroiodic acid.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier Ltd. All rights reserved. This is an author produced version of an article published in Tetrahedron. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Chiral amine racemization; Catalytic transfer hydrogenation dehydrogenation; Catalyst deactivation mechanism; Iridium; Hydrogen borrowing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Dec 2020 11:21 |
Last Modified: | 03 Dec 2021 01:38 |
Status: | Published online |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tet.2020.131823 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168767 |
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